Men experience three (3) main hormones that decline with age; growth hormone, testosterone, and IGF-1. While this is happening, estradiol can be on the rise, which creates a number of undesirable health issues. The high degree of maintenance begins to slow down. The prostate begins to grow, and fat accumulates. The muscles and tendons get weaker. The vertebrate discs begin to get brittle. During these "golden years", 40 and beyond, men are more suseptable to tendon inuries, such as plantar fasciitis, and tennis elbow. Men are more suseptable to hernia's and disc failures. Eventually, erectile dysfunction can set in. Getting old is not a very pretty process. Knowing what we now know about aging, and hormones, we can redefine the term "aging". The main physical difference between a young 25 year old man, and a 60 year old man, is the level of maintenance that is being done, due to the hormone levels and balance. Aging, is synonymous with hormone declination. If you simply restore your hormone balance to that of a younger man, your body maintenance will increase to that younger man's level. Therefore, by our newer definition, you will not have aged. You will have gone back in time, to the maintenance levels of that younger man. Your body will now perform, like that younger man's body. You can go back in time, by using the Time Machine, and regain your youth. I have proven this, by taking the Time Machine, and basically, every man who is taking the Time Machine is doing the same thing. Going back, hormonally speaking, to their younger years.
Growth hormone is normally peaked during adolescence, and declines by 14% per decade thereafter. Adult males produce about 500 micrograms of growth hormone at age 20, 200 micrograms at age 40, and 25 micrograms at age 80. The decline in IGF-1 levels with age matches the decline of growth hormone.
Effects of growth hormone (GH)on the tissues of the body are mainly anabolic. GH acts by interacting with a specific receptor on the surface of cells. Increased height during childhood is the most widely known effect of GH. Height appears to be stimulated by at least two mechanisms: Because polypeptide hormones are not fat-soluble, they cannot penetrate cell membranes. Thus, GH exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway. Through this mechanism GH directly stimulates division and multiplication of chondrocytes of cartilage. GH also stimulates, through the JAK-STAT signaling pathway, the production of insulin-like growth factor 1 (IGF-1). The liver is a major target organ of GH for this process and is the principal site of IGF-1 production. IGF-1 has growth-stimulating effects on a wide variety of tissues. Additional IGF-1 is generated within target tissues, making it what appears to be both an endocrine and an autocrine/paracrine hormone. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth.
Growth hormone also has other effects on the body:
• Increases calcium retention, and increases the mineralization of
• Increases muscle mass by way of "sarcomere hyperplasia"
• Promotes lipolysis
• Increases protein synthesis
• Stimulates the growth of all internal organs excluding the brain
• Plays a role in homeostasis
• Reduces liver uptake of glucose
• Promotes gluconeogenesis in the liver
• Contributes to the maintenance and function of pancreatic islets
• Improves immune system function
Medical research has indicated that the aging pituitary somatotroph cells can still secrete as much growth hormone as the young somatotrophs cells if they are properly stimulated. This leads to the reason for the decline in growth hormone to be caused by the inhibitor, somatostatin. This is the good news. Somatostatin can be inhibited by a natural variant of the B vitamin, called CDP Choline, which is why it is present in the Time Machine.
Testosterone is peaked during the teen and early adult years. Testosterone declines by around 1% per year starting around age 30. What is considered normal is quite a spread. Teens between the ages of 14 and 15 years typically have between 8 to 53 ng/dL of testosterone in their blood, while 16 to 19-year-olds average 200 to 970 ng/dL. Men in their 20s or 30s can expect to have a testosterone level of 270 to 1,080 ng/dL. From 40 to 59 years of age, testosterone levels drop to between 350 and 890 ng/dL. From 60 years on, a typical testosterone level in men is between 350 and 720 ng/dL.
The reason for the drop might not be genetic or age related, but possibly related to environmental factors and other health issues. This information comes from research done by David Handelsman, MD, PhD, professor and director of the ANZAC Research Institute at the University of Sydney.
Testosterone has different function depending upon a persons age. Here we examine the general role of testosterone in adult males. Testosterone affects or helps the following:
• Libido and penile erection frequency
• Regulates acute HPA response under dominance challenge
• Mental and physical energy
• Maintenance of muscle strength and growth
• Reduce cardiovascular disease, by indirect methods, such as reducing visceral fat.
Testosterone activates genes in Sertoli cells, which promote differentiation of spermatogonia.
As testosterone affects the entire body (by enlarging; men have bigger hearts, lungs, liver, etc.), the brain is affected by this "sexual" advancement. Literature shows that attention, memory, and spatial ability are key brain functions affected by testosterone in humans.
Progesterone declines as men age. Progesterone counteract the effects of estrogen in the male body. Men rely on the this hormone to preserve their masculinity. Progesterone (along with DHEA) is a precursor to testosterone. As men age and testosterone begins to decline, estrogen levels steadily rise. As estrogen levels increase, progesterone levels decrease. An increase in progesterone results in a decrease in estrogen..
Symptoms of low progesterone in men include:
• Low libido
• Hair loss
• Weight gain
• Erectile dysfunction
• Impotence· Bone loss
• Muscle loss
In addition, men with low levels of progesterone have a higher risk of developing health conditions, such as osteoporosis, arthritis, prostatism and prostate cancer.
Estrogen dominance is a term used by Dr. John R. Lee, and it describes a condition where a man estrogen is running high, in relation to his testosterone. The balance is off. Even if a man's estrogen levels are low, it is still possible that he will have estrogen dominance, if his testosterone is even lower. The principle cause of estrogen dominance in men is an increase rate of conversion by aromatase of testosterone to estrogen, and exposure to xenoestrogens and phytoestrogens which are hormone-mimicking chemicals found in consumer-based products and even in the air we breathe.
Estrogen dominance, according to Dr. Lee results in elevated visceral fat, and the proliferation of prostate cells, among other unwanted changes in the male body. The solution is to reduce the exposure of xenoestrogens to the body. The Time Machine is already equipped with a number of natural aromatase inhibitors, which slow the conversion of testosterone to estrogen. This is the beginning of restoring the balance, of testosterone to estrogen.