Indole 3 Carbinol is a dietary supplement that is derived from cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale. Indole 3 Carbinol is converted by the digestive tract into diindolylmethane, which is then absorbed into the body.
Indole 3 Carbinol helps to control the level of estradiol by converting it into the weaker form, estriol. Both are forms of estrogen, but when estriol binds to the estrogen receptors, the more powerful estradiol is blocked, and therefore cannot impart it's strong "grow signals". This is quite desirable in the aging male body.
Testosterone rises in the blood with use of diindolylmethane. The reason for this is that 2-hydroxy estrogens have a greater binding affinity for the blood proteins that bind with testosterone in the blood. Therefore these plasma binding proteins will latch on to 2-hydroxy, leaving greater levels of free testosterone in the blood
The 2-hydroxy estrogens promoted by usage also increase testosterone synthesis another way. Estrogen creates a negative hormonal feedback loop to the pituitary gland, where the rate-limiting gonadotropin for testosterone synthesis, luteinizing hormone (LH) is synthesized and released. This means that high blood levels of estrogen, from aromatization of free testosterone, inhibit the release of LH from the pituitary gland. This leads to a unfavorable balance between testosterone and estrogen, testosteron being much lower. These events, however, are nullified by 2-hydroxy, which doesn't provide the negative feedback message to the pituitary induced by estrogen. The end effect is greater testosterone synthesis in the Leydig cells of the testes, as well as lower levels of estrogen and it's associated effects..
Indole-3-carbinol has been tested extensively and consistently exhibits strong antitumor activity via its regulation of estrogen activity and metabolism. Indole-3-carbinol is used for prevention of breast, colon, and other types of cancer. The National Institutes of Health (NIH) has reviewed indole-3-carbinol as a possible cancer preventive agent and is now sponsoring clinical research for breast cancer prevention.
Indole-3-carbinol is also used for fibromyalgia, laryngeal papillomatosis caused by a virus, respiratory papillomatosis caused by a virus, cervical dysplasia, and systemic lupus erythematosus (SLE).
It's ability to control estradiol helps to counter
estrogen dominance in men, and it raises testosterone indirectly. Combined
with a good safety track record, it makes a good ingredient for the Time